https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45256 1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.]]> Wed 26 Oct 2022 20:06:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55187 Wed 24 Apr 2024 10:02:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55184 Wed 24 Apr 2024 09:48:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53399 Thu 23 Nov 2023 13:44:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46571 Fri 25 Nov 2022 11:47:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48660 Fri 24 Mar 2023 16:12:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42271 Fri 19 Aug 2022 14:44:24 AEST ]]>